Eric Goemaere, medical coordinator in South Africa of the organisation, which is also known by its French abbreviation MSF said apathy of governments, donors and the organizations they work with, as well as the global economic crisis, were to blame.
Theres no doubt people will die as a consequence. Its a catastrophe in the making, Goemaere said before the opening of a four-day international AIDS conference in Cape Town.
About a quarter of million Malawians are receiving free anti-retroviral (ARV) HIV/Aids drugs which government says the roll out of free treatment to Aids sufferers has saved many Malawians.
The current development of drug shortage threatens lives of many, with an estimated 1 million people, of the countrys 13 million, is living with HIV/AIDS and of those just over 80,000 is children, according to Malawis National AIDS Commission.
President Bingu wa Mutharika recently disclosed that the there would soon be a local company to produce ARVs locally and export extra drugs to neighbouring countries.
President Mutharika said the company which will produce the Aids drugs may be opened in Malawi later this year.
We will try to get the company going this year, said Mutharika.
The Cape Town Aids conference newsletter said: Amidst a lingering global recession and reports that world leaders are retreating on prior commitments, the 5,000 AIDS researchers, implementers and community leaders gathering in Cape Town this weekend are determined to raise their collective voices.
The conference president, Dr. Julio Montaner of the Geneva-based International AIDS Society, added, Either we move forward or we will fall back. That is the reality we face at this pivotal moment in HIV scale-up.
Malawi with 300 new cases every day, largely among young people and females is affected together with Zimbabwe, Uganda, Congo, Guinea and South Africa.
Goemaere also feared difficulties in getting drugs could reverse decades of work to fight the stigma attached to AIDS: We will be going back to the dark times with people thinking that treatment is not reliable or not accessible, so lets hide the disease.
The United Nations last month warned governments against using the global economic crisis as an excuse to cut funding for fighting AIDS at a time when there are nearly five new HIV infections for every two people put on treatment.
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